Biological mechanisms of cancer-related fatigue in breast cancer survivors after treatment: a scoping review.

PURPOSE: Cancer-related fatigue (CRF) is the most common symptom experienced by cancer survivors. It is a multidimensional symptom affecting physical, emotional, and/or cognitive spheres, different from other types of fatigue. Characteristically is not alleviated by sleep or rest. CRF could have specific features in breast cancer survivors (BCS), because of sex, hormones, and distinct treatments. On the other hand, more than 25% of BCS report persistent CRF for 10 years or more after the diagnosis. The present study aims to recapitulate the knowledge about the biological mechanisms that potentially drive CRF in BCS after treatment. METHODS: To answer a broad question, a scoping review methodology was used. Data were collated from three bibliographic databases: PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL). Studies were selected if they had included more than 20 BCS, after finishing their treatment, fatigue was measured with a quantitative scale and biomarkers were analyzed. RESULTS: The final database was composed of 1896 records. Sixty-four studies finally met the eligibility criteria. Inflammation (61%), hypothalamic-pituitary-adrenal (HPA) axis dysregulation (14%), autonomic nervous system (ANS) dysfunction (11%), and diet (9%) were the biological pathways most frequently studied. Unfortunately, results from studies about inflammation and HPA axis show many inconsistencies. CONCLUSION: More research about the role of ANS dysfunction and diet on the pathogenesis of CRF would be warranted according to the results of the review. There are some fields such as endocannabinoid systems, mitochondrial dysfunction, gut microbiota, and oxidative stress that have been insufficiently explored. IMPLICATIONS FOR CANCER SURVIVORS: To widen the scope of future research in the physiopathology of CRF, it is necessary to identify mechanisms that would be potentially involved and have been insufficiently explored. Because of the high prevalence of CRF in BCS and the tremendous impact that fatigue has in their quality of life, it is essential to improve the efficacy of the treatments through a good knowledge of the biological basis of CRF.

[Implications on the scientific production of COVID-19.] / Consecuencias en la producción científica de la COVID-19.

The impact and the universality of the pandemic by SARS-CoV-2 has caused the need to have information quickly and accessible for the benefit of decision-making among healthcare professionals. In 10 months the scientific production on this new coronavirus has exceeded the number of 66 thousand articles, according to the LitCovid database, created by the National Library of Medicine, doubling and tripling every few weeks. This same urgency has characterized some of the main features of this voluminous production, in addition to its continuous and exponential growth, such as greater dissemination in open access and preprint repositories, a certain acceleration in the manuscript review process by editorials and an abundance of opinion articles, recommendations or comments compared to a smaller number of original articles with clinical data from large groups of patients.

El impacto y la universalidad de la pandemia de SARS-CoV-2 han provocado en el mundo entero la necesidad de disponer de información científica de una forma rápida y accesible para la correcta toma de decisiones entre los profesionales sanitarios. Por ello, en 10 meses la producción científica sobre este nuevo coronavirus ha superado la cifra de los 66.000 artículos, según la base de datos LitCovid creada por la National Library of Medicine, duplicándose y triplicándose la cantidad cada pocas semanas. Esta misma urgencia ha caracterizado algunos de los rasgos principales que han definido esta voluminosa producción, además de su continuo y exponencial crecimiento, como son una mayor difusión en acceso abierto y en repositorios de preprints, una cierta aceleración en el proceso de revisión de manuscritos por parte de las editoriales y una abundancia de artículos de opinión, recomendaciones o comentarios frente a un menor número de artículos originales con datos clínicos de grandes grupos de pacientes.

Estudio histórico hemerográfico sobre la Escuela Nacional de Puericultura. Antecedentes de la Pediatría Social y mirada crítica a la maternología y la perspectiva de género / Historical newspaper study on the National School of Childcare. History of Social Paediatrics as well as a critical look at maternity medicine and the gender perspective

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Los sueños durante la hospitalización, valor de su narrativa plástica como forma de humanización de la asistencia / Dreams during hospitalization, value of their plastic narrative as a way to humanize assistance

Introducción: el sueño, con su contenido simbólico, genera ritmos de imágenes que sirven para expresar emociones y vivencias. Objetivo: representar gráficamente, por una alumna del Grado Superior de Ilustración, las emociones de los niños ingresados en el Hospital Universitario de Fuenlabrada, expresadas a través de sus sueños. Ayudarles a poner de manifiesto sus sentimientos, deseos y necesidades, e integrar, mediante la escritura y el dibujo, la enfermedad o el motivo de hospitalización. Métodos: estudio cualitativo, aprobado por el Comité Ético del Hospital Universitario de Fuenlabrada. Muestreo abierto, objetivo inicial: buscar saturación o diversidad temática. Inclusión: edad 7-12 años, firma del consentimiento. Material: cuaderno de recogida de sueños. El estudio se realizó en tres sesiones: presentación del proyecto a la familia y cuaderno de recogida de sueños; narración y dibujo infantil en el cuaderno de recogida de sueños; ilustración del sueño por la alumna del Grado Superior de Ilustración, puesta en común con el niño y su familia. Resultados: los textos o los dibujos de los niños fueron la base estética para las ilustraciones, con aportación metafórica y utilizando características del surrealismo. Sueños válidos obtenidos para ilustrar: "Ayuda a los demás", "Entre dos mundos", "Soy un elfo". Este estudio se consideró piloto. Se realizó un proyecto de final de grado de la alumna, un álbum ilustrado, Oniros, y una exposición temporal en el hospital. Conclusiones: la narración y el diseño pictórico de los sueños de los niños durante el ingreso colaboran en la expresión de sus emociones y necesidades y generan empatía en el entorno. El protagonismo de los niños y sus padres en actividades culturales en el medio hospitalario genera actitudes positivas

Introduction: the dream, its symbolic content, produces images to express emotions and experiences. Objective: a student of Diploma in Illustration represents by pictures the emotions felt by children during their hospital stay, expressed through their dreams in order to help them express their feelings, desires, needs, integrating through writing and drawing the illness or the reason for hospitalization. Methods: qualitative study, approved by the Hospital Universitario de Fuenlabrada Ethics Committee. Open sampling pretending saturation or variety. Inclusion criteria: age 7-12 years, prior signature of the informed consent. Material: notebook to jot down the dreams. The study was carried out in three sessions: presentation of the project to the family and delivery of the notebook, narration and children's drawing in their notebook; illustration of the dream by the student of Diploma in Illustration, shared with the child and his family. Results: the texts and/or the drawings of the children were the aesthetic basis for the illustrations, concretizing them with metaphorical contribution and using certain characteristics of surrealism. Three valid dreams were obtained to illustrate: "Help the others", "Between two worlds", "I'm an elf". This study was considered pilot and was presented as end-of-year project, along with the illustrated album Oniros. Subsequently, a temporary exhibition was held in the hospital. Conclusions: the narrative and the pictorial design of the children's dreams during admission contributes to the expression of their emotions and needs, and generates empathy in the environment. The leadership of children and their parents in cultural activities in the hospital generates positive attitudes

Uso de epónimos en revistas pediátricas en español en los últimos 10 años ¿está cambiando? / Use of eponyms in Spanish in paediatric journals over the last ten years. Is it changing?

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